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  • Equipment

    The facility allows for the use of commercially available strains of mice, C57BL/6 and Swiss-Webster are stocked and maintained in the facility year-round. All mice are housed in flexible film positive pressure isolators to aid in the preservation of a germ-free status. 

     

We are a BSL2 facility and can support many infectious pathogens. In addition, we can “humanize” the microbiota of mice, with transfers from patients, carry out tumor injections to test for tumor immunotherapy, and administer drugs, biologics, etc. Our facility provides all of the husbandry and upkeep for these mice, and assistance in gavaging or otherwise associating mice with microbiota is possible. We can also assist with experimental procedures within the bubbles at your request.

 

Gnotobiotic Animal Core Laboratory
Gnotobiotic Animal Core

The Pitt Gnotobiotic facility is a fee-for-service core that allows for experiments requiring germ-free (without bacteria, fungi, and exogenous viruses) and gnotobiotic (“known microbiota”) mice. Germ-free mice allow you to test the necessity and sufficiency of any microorganism or collection of organisms on a phenotype. Mice are kept in positive-pressure flexible film isolators. The germ-free status of the mice is re-confirmed periodically through third party microbiological testing.

Resources

Gnotobiotic Facility Request Form
Gnotobiotic Facility Request Form
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Additional information
Additional information